منابع مشابه
High frequency skin ultrasonography in systemic sclerosis
Background: Systemic sclerosis is an autoimmune connective tissue disorder which is characterised by cutaneous and internal organ fibrosis. Raynaud’s phenomenon is the earliest feature and may precede the onset of the disease by months to years. The heart, lungs, gastrointestinal tract, kidneys and other organs may be involved. Our aim was to evaluate skin thickness and echogenicity in systemic...
متن کاملThe roles of chemokines in leukocyte recruitment and fibrosis in systemic sclerosis.
Systemic sclerosis (SSc, scleroderma) is an autoimmune disease characterized by excessive extracellular matrix deposition and vascular injury in the skin and other visceral organs. Although the pathogenesis remains unclear, interactions among leukocytes, endothelial cells, and fibroblasts are likely to be central to the pathogenesis of the disease. Chemokines mediate the leukocyte chemotaxis an...
متن کاملChemokines and Chemokine Receptors in Multiple Sclerosis
Multiple sclerosis is an autoimmune disease with classical traits of demyelination, axonal damage, and neurodegeneration. The migration of autoimmune T cells and macrophages from blood to central nervous system as well as the destruction of blood brain barrier are thought to be the major processes in the development of this disease. Chemokines, which are small peptide mediators, can attract pat...
متن کاملChemokines in chronic progressive neurological multiple sclerosis
Chemokines are 8 ± 12 kd chemoattractant cytokines characterized by a four cysteine motif (Luster, 1998; Ransohoff et al, 1996; Schall, 1994; Taub, 1996). The presence or absence of an intervening amino acid(s) (X) between the N terminal cysteines de®nes the CXC/CX3C and CC families, respectively. A third family, C chemokines, lacks an N terminal cysteine but is otherwise homologous. It was ori...
متن کاملAssociation between atherosclerosis and parenchymal lung involvement in systemic sclerosis
Background: Systemic sclerosis is an autoimmune disease affecting connective tissues, (including epidermal, subepidermal, microvasculature, etc.), leading to various extent of end-organ damage. The leading cause of mortality among these patients is lung involvement. The cardiovascular events happen more frequently in patients suffering systemic scleroderma, comparing to healthy population. This...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunology Letters
سال: 2018
ISSN: 0165-2478
DOI: 10.1016/j.imlet.2017.12.001